Morphology & Cell Analysis Core
The Morphology & Cell Analysis Core of the Harvard Skin Disease Research Center (HSDRC) facilitates basic research by helping investigators access tissue, equipment, and technology; technical assistance and training; and expertise in planning and analysis.
Tissue, Equipment, and Technology: The core uses a human tissue archive based in the BWH Department of Pathology. Tissue sections and tissue microarrays (TMAs) are available to add translational relevance to more basic experimental approaches. Physical resources for basic skin research are available.
Technical Assistance and Training: We can guide the development, application, and analysis of morphologically-relevant model systems, including skin organ culture and human skin-SCID mouse xenografts. We also provide training in the use of equipment in our lab.
Expertise: We can share insights from our many years of experience in dermatopathology research and provide professional analysis. We can also introduce investigators to specialists at BWH and affiliated institutions.
Clinical Research: Skin SPORE Biospecimen Access & Analysis Core
The Biospecimen Access & Analysis Core of the Harvard Specialized Program of Research Excellence (SPORE) in Skin Cancer facilitates clinical research by providing services for obtaining, processing, analyzing, archiving and retrieving human biospecimens.
The specific aims of the Core are to assist SPORE and other investigators with the following technical and professional analytical and educational (training) services:
1. Specialized morphology and morphometry
2. Fine-structural analysis
3. Molecular analysis
4. Genomic analysis
5. Relevant experimental modeling
6. Tissue archives
7. Education and training
To get started using the core, please send an email.
The Biospecimen Access and Analysis Core for the Harvard SPORE provides technical and professional expertise to investigators in the areas of specialized pathological analysis of intact tissues and cells as well as preservation, archiving, and retrieval of relevant tissue samples. Accumulated biospecimens, technology, professional expertise, and partnerships are strengths of the core. The Core is integrated with the Dana Farber/Harvard Cancer Center (DF/HCC) and is housed in the same building as the BWH Dermatology Clinic.
Professional and Technical Analyses
- Use of formalin-fixed paraffin-embedded biospecimens for gene expression signatures
- Immuno-guided laser capture microdissection (LCM)
- Planning and assembly of tissue microarrays (TMAs)
- Frozen tissue microarrays
- Quantification of probe reactivity in biospecimens
- Correlative melanoma/CTCL immunophenotyping
- Human skin/murine xenograft model
- Three-dimensionsional organotypic reconstruct model
- Quantum dots for tissue imaging
- Other Lab Technqiues