Thank you to Partners Healthcare and to the National Institutes of Health (the National Cancer Institute; the National Institute for Arthritis, Muskuloskeletal, and Skin Disease; and the National Heart, Lung, and Blood Institute) for supporting our numerous research initiatives. Through these sponsors, members of the BWH Program in Dermatopathology have been awarded or have received funds from the following grants:
- Harvard skin disease research center – Morphology and cell analysis core (2P30AR042689-16)
This encompasses numerous projects whereby the Program in Dermatopathology provides professional and technical analyses for basic translational initiatives involving skin biology and cancer for BWH, MGH, CHMC, BIDMC, and DFCI investigators, as well as for external collaborators.
- Harvard SPORE in skin cancer – Biospecimen access and analysis core (5P50CA093683-07)
This project involves management of tissue archiving and training in specialized morphology.
- Harvard SPORE in skin cancer – ABCB5 and melanoma stem cells (5P50CA093683-07)This project examines the diagnostic, translational, and therapeutic relevance of ABCB5 as a biomarker for melanoma stem cells.
- Melanoma stem cells, vasculogenesis and neoplastic progression (5R01CA138231-03)
This grant examines the role of ABCB5-positive melanoma stem cells in the induction and maintenance of vasculogenic genes in human and experimental melanoma.
- BMP7 Melanoma Niche Morphogenesis and Homeostasis (1R01CA138649-01A2)
Our current study is aimed at defining the underlying structural and mechanistic bases through which CD133+ melanoma initiating cells (MICs) influence their microenvironment, also known as the “niche”, to support tumor survival and growth. Particularly, we will elucidate how MIC-associated BMP7 signaling contributes to “niche” morphogenesis and tumor heterogeneity/homeostasis using both organotypic ex vivo and orthotopic in vivo experimental models. We anticipate that our findings should provide novel insights into therapeutically target MICs directly or indirectly through their stromal dependency.
- Cellular pathology of graft-versus-host disease (5R01HL084815-19)
The major goals of this project are to explore and understand mechanisms of selective target cell injury in experimental GVHD in order to prevent disease by local inhibition of effector pathways at the target site.
- Mechanisms of graft-versus-host disease – Immune assessment core (9P01CA142106-06A1)
This project focuses on the immunohistochemical assessment of human GVHD biopsies in order to study responses to specific therapeutic protocols.
- Immune modulation after allogenic hematopoietic cell transplantation: delayed regulation of GVHD with retained GVL effect (5U19AI029530-18)
The major goal of this project is to explore the role of regulatory T cells to better understand how these cells might abrogate GVHD morbidity and mortality while preserving GVL effects.